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In Vivo Solid‐Phase Microextraction: Capturing the Elusive Portion of Metabolome
Author(s) -
Vuckovic Dajana,
de Lannoy Inés,
Gien Brad,
Shirey Robert E.,
Sidisky Leonard M.,
Dutta Sucharita,
Pawliszyn Janusz
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006715
Subject(s) - solid phase microextraction , metabolome , ultrafiltration (renal) , computer science , chromatography , dried blood , chemistry , metabolomics , mass spectrometry , gas chromatography–mass spectrometry
Metabolites with fast turnover rates and/or unstable metabolites can be captured directly from circulating blood using a new solid‐phase microextraction (SPME) device based on a hypodermic needle. Such metabolites are not observed using solvent precipitation and ultrafiltration methods, indicating traditional approaches based on blood withdrawal are not adequately capturing complete metabolome at the time of sampling.