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Shuttle‐Mediated Drug Delivery to the Brain
Author(s) -
Malakoutikhah Morteza,
Teixidó Meritxell,
Giralt Ernest
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006565
Subject(s) - drug , drug delivery , blood–brain barrier , neuroscience , site of action , central nervous system , medicine , drug delivery to the brain , brain disease , pharmacology , biology , chemistry , disease , organic chemistry
Advances in the field of shuttle‐mediated drug delivery have been made in the last decade; however, the treatment of brain disorders still remains a great challenge because of the presence of the blood–brain barrier (BBB), a structure that limits the access of drugs to their site of action in the central nervous system. Several strategies have been proposed to enhance the transport of drugs across the BBB. In this Review, we focus on the vector‐mediated approach, in which a drug is coupled to a molecule (shuttle) that has the ability to cross the BBB and deliver the drug to the brain.