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Self‐Assembled Arrays of Dendrimer–Gold‐Nanoparticle Hybrids for Functional Cell Studies
Author(s) -
Lundgren Anders,
Hed Yvonne,
Öberg Kim,
Sellborn Anders,
Fink Helen,
Löwenhielm Peter,
Kelly Jonathan,
Malkoch Michael,
Berglin Mattias
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006544
Subject(s) - dendrimer , polyethylene glycol , peg ratio , nanotechnology , nanoparticle , macromolecule , colloidal gold , adhesion , chemistry , materials science , biophysics , polymer chemistry , biology , biochemistry , organic chemistry , finance , economics
Dendrimer‐controlled cell growth : A dendrimer–gold‐nanoparticle hybrid array (see picture; PEG=polyethylene glycol), which can control the apparent dendrimer surface density, was used to investigate cell adhesion. The effect of the macromolecular architecture on the attachment and the morphological development of endothelial cells was studied. The dendrimer outperformed a linear counterpart, most likely modulated by the different interactions between the dendrimer and the proteins in the cell media.