Premium
Inside Cover: “Illusionary” Polymerase Activity Triggered by Metal Ions: Use for Molecular Logic‐Gate Operations (Angew. Chem. Int. Ed. 50/2010)
Author(s) -
Park Ki Soo,
Jung Cheulhee,
Park Hyun Gyu
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006534
Subject(s) - cover (algebra) , polymerase , polymerase chain reaction , chemistry , dna , microbiology and biotechnology , biology , biochemistry , engineering , gene , mechanical engineering
“Illusionary” polymerase activity was proved to be intentionally triggered by Hg 2+ and Ag + ions through their interaction with the mismatched base pairs T–T and C–C to result in a nonnatural amplification reaction. In their Communication on page 9757 ff., H. G. Park and co‐workers describe how rational design of the primers and selection of the type of DNA polymerase was used to construct molecular‐scale logic gates.