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Total Synthesis and Absolute Stereochemistry of Seragakinone A
Author(s) -
Takada Akiomi,
Hashimoto Yoshimitsu,
Takikawa Hiroshi,
Hikita Katsuyoshi,
Suzuki Keisuke
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006528
Subject(s) - absolute (philosophy) , total synthesis , chemistry , absolute configuration , stereochemistry , philosophy , epistemology
Cyclic transformation : The key transformations of the asymmetric total synthesis of the marine‐derived natural product seragakinone A are two N‐heterocyclic carbene catalyzed benzoin cyclizations that result in the construction of two rings and a pinacol‐type rearrangement to install the angular prenyl substituent.