Premium
Multicomponent Reaction Design in the Quest for Molecular Complexity and Diversity
Author(s) -
Ruijter Eelco,
Scheffelaar Rachel,
Orru Romano V. A.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006515
Subject(s) - serendipity , diversity (politics) , computer science , rational design , nanotechnology , biochemical engineering , data science , chemistry , epistemology , political science , materials science , engineering , philosophy , law
Multicomponent reactions have become increasingly popular as tools for the rapid generation of small‐molecule libraries. However, to ensure sufficient molecular diversity and complexity, there is a continuous need for novel reactions. Although serendipity has always played an important role in the discovery of novel (multicomponent) reactions, rational design strategies have become much more important over the past decade. In this Review, we present an overview of general strategies that allow the design of novel multicomponent reactions. The challenges and opportunities for the future will be discussed.