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Control of the Chirality and Helicity of Oligomers of Serinol Nucleic Acid (SNA) by Sequence Design
Author(s) -
Kashida Hiromu,
Murayama Keiji,
Toda Takasuke,
Asanuma Hiroyuki
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006498
Subject(s) - nucleic acid , chirality (physics) , chemistry , nucleobase , sequence (biology) , stereochemistry , dna , peptide nucleic acid , rna , nucleic acid analogue , combinatorial chemistry , nucleic acid thermodynamics , biochemistry , base sequence , physics , quantum mechanics , nambu–jona lasinio model , quark , chiral symmetry breaking , gene
Mimicking the masters : An artificial nucleic acid, serinol nucleic acid (SNA), formed oligomers in which natural nucleobases were tethered through its 2‐amino‐1,3‐propanediol (serinol) scaffold. These SNA oligomers have two unique properties: their chirality is controllable by sequence design and can be inverted by reversing the sequence (see picture), and they can cross‐hybridize with DNA and RNA with sufficient thermal stability.