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A Coordinated Synthesis and Conjugation Strategy for the Preparation of Homogeneous Glycoconjugate Vaccine Candidates
Author(s) -
Grayson Elizabeth J.,
Bernardes Gonçalo J. L.,
Chalker Justin M.,
Boutureira Omar,
Koeppe Julia R.,
Davis Benjamin G.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006327
Subject(s) - glycoconjugate , homogeneous , computer science , scheme (mathematics) , oligosaccharide , glycoprotein , information retrieval , computational biology , chemistry , biochemistry , biology , mathematics , combinatorics , mathematical analysis
A sweet solution : A strategy for the synthesis of well‐defined carbohydrate‐based vaccines is presented. The approach couples complex oligosaccharide synthesis to site‐specific conjugation methodology to provide pure glycoprotein vaccine candidates (see scheme).