Premium
The Catalytic Asymmetric Knoevenagel Condensation
Author(s) -
Lee Anna,
Michrowska Anna,
SulzerMosse Sarah,
List Benjamin
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006319
Subject(s) - knoevenagel condensation , catalysis , amine gas treating , chemistry , condensation , cinchona , organic chemistry , combinatorial chemistry , computer science , enantioselective synthesis , physics , thermodynamics
116 years after the discovery of the Knoevenagel condensation , the first catalytic asymmetric variant has been developed. Dynamic kinetic resolution in the reaction of α‐branched aldehydes with malonates in the presence of a newly designed and readily available modified cinchona amine catalyst gives the corresponding alkylidene malonates in high enantioselectivity (see scheme).