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Safe and Efficient Tetrazole Synthesis in a Continuous‐Flow Microreactor
Author(s) -
Palde Prakash B.,
Jamison Timothy F.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006272
Subject(s) - scope (computer science) , scalability , computer science , microreactor , safer , line (geometry) , residual , scheme (mathematics) , continuous flow , process engineering , combinatorial chemistry , database , chemistry , programming language , algorithm , biochemical engineering , computer security , engineering , mathematics , organic chemistry , geometry , catalysis , mathematical analysis
Safer flow : The synthesis of 5‐substituted tetrazoles in flow (see scheme) is safe, efficient, scalable, requires no metal promoter, and uses a near‐equimolar amount of NaN 3 , yet nonetheless displays a broad substrate scope. The hazards associated with HN 3 are essentially eliminated, shock‐sensitive metal azides such as Zn(N 3 ) 2 are avoided, and residual NaN 3 is quenched in‐line with NaNO 2 .