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Rhodium‐Catalyzed Oxidative Olefination of CH Bonds in Acetophenones and Benzamides
Author(s) -
Patureau Frederic W.,
Besset Tatiana,
Glorius Frank
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006222
Subject(s) - rhodium , catalysis , oxidative phosphorylation , chemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , biochemistry
A good neighborhood! The metal‐catalyzed oxidative CH functionalization of electron‐rich arenes is well‐established, but analogous reactions of electron‐poor substrates are rare. A new application makes use of common electron‐withdrawing functional groups (COMe, CONH 2 , CONEt 2 ) in the rhodium‐catalyzed oxidative Heck reaction to generate complex organic molecules. Cp*= η 5 ‐C 5 Me 5.