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Coupling of Luminescent Terbium Complexes to Fe 3 O 4 Nanoparticles for Imaging Applications
Author(s) -
Wang Baodui,
Hai Jun,
Wang Qin,
Li Tianrong,
Yang Zhengyin
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006195
Subject(s) - terbium , folate receptor , nanoparticle , hela , superparamagnetism , folic acid , luminescence , fluorescence , coupling (piping) , chemistry , combinatorial chemistry , nanotechnology , in vitro , computer science , materials science , optoelectronics , physics , biochemistry , optics , biology , cancer cell , medicine , magnetization , cancer , genetics , quantum mechanics , magnetic field , metallurgy
Dual imaging agent : A fluorescent Tb III complex coupled to Fe 3 O 4 nanoparticles and bearing a folic acid residue (see picture) shows superparamagnetism, low cytotoxicity, and high cell uptake, and thus can be used for in vitro fluorescence and magnetic resonance imaging of cells that overexpress the folate receptor, such as HeLa cells.