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Diastereoselective Carbometalation of Oxa‐ and Azabicyclic Alkenes under Iron Catalysis
Author(s) -
Ito Shingo,
Itoh Takuma,
Nakamura Masaharu
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006180
Subject(s) - electrophile , heteroatom , reagent , chemistry , combinatorial chemistry , organic chemistry , catalysis , ring (chemistry)
Highly diastereoselective carbometalation of oxa‐ and azabicyclic alkenes with arylzinc reagents has been achieved by using FeCl 3 and novel ortho ‐phenylene diphosphine ligands (see scheme; E=electrophile). The carbozincation products are stable towards β‐heteroatom elimination and can be trapped with various electrophiles.