Divergolides A–D from a Mangrove Endophyte Reveal an Unparalleled Plasticity in ansa‐Macrolide Biosynthesis | Zendy

Ding Ling | Zendy; Maier Armin | Zendy; Fiebig HeinzHerbert | Zendy; Görls Helmar | Zendy; Lin WenHan | Zendy; Peschel Gundela | Zendy; Hertweck Christian | Zendy

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Divergolides A–D from a Mangrove Endophyte Reveal an Unparalleled Plasticity in ansa‐Macrolide Biosynthesis

Author(s) -

Ding Ling,

Maier Armin,

Fiebig HeinzHerbert,

Görls Helmar,

Lin WenHan,

Peschel Gundela,

Hertweck Christian

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201006165

Subject(s) - endophyte , diversification (marketing strategy) , biology , mangrove , biogenesis , botany , ecology , biochemistry , business , gene , marketing

In‐built diversification : Four ansa macrolides, divergolides A–D ( 1 – 4 ), with intriguing structures were isolated from a bacterial endophyte of the mangrove tree Bruguiera gymnorrhiza. These compounds are generated by a common biogenesis from a linear precursor that undergoes various reactions to give the multicyclic structures. This remarkable plasticity results in metabolites with different antibacterial and cytotoxic properties.

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