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Divergolides A–D from a Mangrove Endophyte Reveal an Unparalleled Plasticity in ansa‐Macrolide Biosynthesis
Author(s) -
Ding Ling,
Maier Armin,
Fiebig HeinzHerbert,
Görls Helmar,
Lin WenHan,
Peschel Gundela,
Hertweck Christian
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006165
Subject(s) - endophyte , diversification (marketing strategy) , biology , mangrove , biogenesis , botany , ecology , biochemistry , business , gene , marketing
In‐built diversification : Four ansa macrolides, divergolides A–D ( 1 – 4 ), with intriguing structures were isolated from a bacterial endophyte of the mangrove tree Bruguiera gymnorrhiza. These compounds are generated by a common biogenesis from a linear precursor that undergoes various reactions to give the multicyclic structures. This remarkable plasticity results in metabolites with different antibacterial and cytotoxic properties.