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Removable Directing Groups in Organic Synthesis and Catalysis
Author(s) -
Rousseau Géraldine,
Breit Bernhard
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006139
Subject(s) - reagent , catalysis , intramolecular force , organic synthesis , substrate (aquarium) , combinatorial chemistry , stoichiometry , functional group , chemistry , selectivity , nanotechnology , organic chemistry , materials science , oceanography , polymer , geology
Abstract Directing groups have been widely used in recent years to achieve control over all aspects of reaction selectivity in a wide range of transformations involving transition‐metal catalysis and organometallic reagents. In cases when the existing functional group within a substrate is unsuited to achieve efficient intramolecular delivery of a reagent or catalyst, the specific introduction of an appropriately designed removable reagent‐directing group can be a solution to this problem. In this Review we give an overview of the state of the art in this area, including the stoichiometric and catalytic use of directing groups.