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Regioselective Rhodium(II)‐Catalyzed Hydroaminations of Propargylguanidines
Author(s) -
Gainer Morgan J.,
Bennett Nitasha R.,
Takahashi Yu,
Looper Ryan E.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006087
Subject(s) - hydroamination , rhodium , regioselectivity , chemistry , dig , combinatorial chemistry , stereochemistry , computer science , catalysis , organic chemistry , world wide web
Different than others : Dimeric rhodium(II) carboxylates uniquely catalyze the 6‐ endo ‐dig selective hydroamination of propargylguanidines while tranditional π‐Lewis acids are typically 5‐ exo ‐dig selective (see scheme, oct=octanoate). Furthermore, this represents a new role for Rh II to activate alkynes for addition chemistry.
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