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Dearomatization Strategies in the Synthesis of Complex Natural Products
Author(s) -
Roche Stéphane P.,
Porco John A.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201006017
Subject(s) - total synthesis , natural product , enantioselective synthesis , natural (archaeology) , nanotechnology , chemistry , biochemical engineering , combinatorial chemistry , computer science , organic chemistry , materials science , engineering , biology , catalysis , paleontology
Evolution in the field of the total synthesis of natural products has led to exciting developments over the last decade. Numerous chemoselective and enantioselective methodologies have emerged from total syntheses, resulting in efficient access to many important natural product targets. This Review highlights recent developments concerning dearomatization, a powerful strategy for the total synthesis of architecturally complex natural products wherein planar, aromatic scaffolds are converted to three‐dimensional molecular architectures.