Premium
Palladium(II)‐Catalyzed CH Bond Arylation of Electron‐Deficient Arenes at Room Temperature
Author(s) -
Tredwell Matthew J.,
Gulias Moises,
Gaunt Bremeyer Nadine,
Johansson Carin C. C.,
Collins Beatrice S. L.,
Gaunt Matthew J.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005990
Subject(s) - palladium , imine , catalysis , aryl , chemistry , medicinal chemistry , combinatorial chemistry , polymer chemistry , organic chemistry , alkyl
Mild and tolerant : A novel Pd II ‐catalyzed CH bond arylation with aryl‐BF 3 K salts transforms various electron‐deficient arenes under mild reaction conditions. Benzaldehydes are functionalized in the ortho position using a temporary imine directing group that controls the cyclopalladation. A broad range of benzaldimines are compatible with this process (see scheme).