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Orthogonal Protein Decoration of DNA Origami
Author(s) -
Saccà Barbara,
Meyer Rebecca,
Erkelenz Michael,
Kiko Kathrin,
Arndt Andreas,
Schroeder Hendrik,
Rabe Kersten S.,
Niemeyer Christof M.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005931
Subject(s) - dna origami , dna , computational biology , biology , genetics
If the face fits : Self‐labeling fusion proteins have been used for the site‐specific decoration of DNA origami. This method even allows individual faces of the quasi‐two‐dimensional plane of the nanostructure to be specifically decorated (see picture), thereby enabling directional immobilization and thus control over the accessibility of distinct proteins presented on the structure.