Premium
Cobalt‐ and Manganese‐Catalyzed Direct Amination of Azoles under Mild Reaction Conditions and the Mechanistic Details
Author(s) -
Kim Ji Young,
Cho Seung Hwan,
Joseph Jomy,
Chang Sukbok
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005922
Subject(s) - amination , catalysis , chemistry , cobalt , manganese , combinatorial chemistry , pharmacophore , primary (astronomy) , substrate (aquarium) , ammonia , peroxide , organic chemistry , stereochemistry , physics , oceanography , astronomy , geology
A bonding moment : A new cobalt‐ or manganese‐catalyzed amination of azoles has been developed using peroxide and an acid additive to couple various types of azoles with ammonia, and primary or secondary amines (see scheme). The catalyst loadings are low, the optimal reaction conditions are mild, and the substrate scope is broad. The product azoles are an important pharmacophore of high biological activity.