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Highly Efficient Capture of Circulating Tumor Cells by Using Nanostructured Silicon Substrates with Integrated Chaotic Micromixers
Author(s) -
Wang Shutao,
Liu Kan,
Liu Jian,
Yu Zeta T.F.,
Xu Xiaowen,
Zhao Libo,
Lee Tom,
Lee Eun Kyung,
Reiss Jean,
Lee YiKuen,
Chung Leland W. K.,
Huang Jiaoti,
Rettig Matthew,
Seligson David,
Duraiswamy Kumaran N.,
Shen Clifton K.F.,
Tseng HsianRong
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005853
Subject(s) - haystack , circulating tumor cell , computer science , polydimethylsiloxane , nanotechnology , silicon , microfluidics , tumor cells , materials science , cancer research , cancer , world wide web , optoelectronics , biology , medicine , metastasis
Finding a needle in a haystack : A new technology is demonstrated to enrich circulating tumor cells (CTCs) with high efficiency by integrating an antibody‐coated silicon nanopillar (SiNP, see picture; gray) substrate with an overlaid polydimethylsiloxane (PDMS) microfluidic chaotic mixer (turquoise). It shows significantly improved sensitivity in detecting rare CTCs from whole blood, thus providing an alternative for monitoring cancer progression.