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The Leiodolide B Puzzle
Author(s) -
Larivée Alexandre,
Unger John B.,
Thomas Mikaël,
Wirtz Conny,
Dubost Christophe,
Handa Shinya,
Fürstner Alois
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005850
Subject(s) - set (abstract data type) , computer science , information retrieval , content (measure theory) , diastereomer , stereochemistry , mathematics , chemistry , programming language , mathematical analysis
Out of options? Even though a systematic approach was chosen, which led to a set of four diastereomeric macrolides modeled around the proposed structure of leiodolide B (see picture), the puzzle concerning the stereostructure of this cytotoxic metabolite derived from a deep‐sea sponge still remains unsolved.
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