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Synthetic and Theoretical Investigations of Myrmicarin Biosynthesis
Author(s) -
Snyder Scott A.,
ElSohly Adel M.,
Kontes Ferenc
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005825
Subject(s) - oligomer , monomer , block (permutation group theory) , quantum chemical , chemistry , combinatorial chemistry , order (exchange) , biosynthesis , scheme (mathematics) , nanotechnology , biochemical engineering , computer science , materials science , organic chemistry , molecule , mathematics , engineering , polymer , geometry , finance , economics , enzyme , mathematical analysis
Off to a good start : Use of a carefully designed building block coupled with several highly selective reactions has enabled the syntheses of the monomeric myrmicarins (see scheme) and the investigation of higher‐order oligomer synthesis by enabling access to previously unobtainable stereochemical arrangements. These studies, in combination with quantum chemical calculations, question whether the higher‐order structures can be obtained through acid‐promoted biomimetic synthesis.