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Coupling of N ‐Tosylhydrazones with Terminal Alkynes Catalyzed by Copper(I): Synthesis of Trisubstituted Allenes
Author(s) -
Xiao Qing,
Xia Ying,
Li Huan,
Zhang Yan,
Wang Jianbo
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005741
Subject(s) - diazo , chemistry , copper , carbene , catalysis , combinatorial chemistry , coupling (piping) , terminal (telecommunication) , allene , medicinal chemistry , organic chemistry , computer science , materials science , telecommunications , metallurgy
The easy way to allenes : An operationally simple reaction under mild conditions has led to the direct formation of trisubstituted allenes (see scheme; Ts=4‐toluenesulfonyl). An unprecedented copper–carbene migratory insertion process seems to take place, in contrast to classic copper(I)‐catalyzed reactions of diazo compounds.