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The Insatiable Quest for Near‐Infrared Fluorescent Probes for Molecular Imaging
Author(s) -
Achilefu Samuel
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005684
Subject(s) - förster resonance energy transfer , bioluminescence , fluorescence , energy transfer , luciferase , infrared , chemistry , bioluminescence imaging , fluorescence lifetime imaging microscopy , biophysics , preclinical imaging , fluorescent protein , in vivo , green fluorescent protein , nanotechnology , physics , materials science , biology , optics , biochemistry , transfection , chemical physics , microbiology and biotechnology , gene
A multitalented protein : Fluorescence and bioluminescence resonance energy transfer, FRET and BRET, respectively, are viable strategies for the generation of near‐infrared light for in vivo imaging. In a recent ground‐breaking study, luciferase was used first to mediate the growth and stability of quantum dots and then as a light source for BRET (see picture).
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