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Dorsomorphin Promotes Human Embryonic Stem Cell Self‐Renewal
Author(s) -
Gonzalez Rodolfo,
Lee Jae Wook,
Snyder Evan Y.,
Schultz Peter G.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005659
Subject(s) - embryonic stem cell , autocrine signalling , stem cell , biology , computational biology , embryo , microbiology and biotechnology , genetics , gene , cell culture
Self‐renewal promoter : Using a high‐throughput screening assay, the small molecule dorsomorphin (see scheme) was identified as a positive regulator of human embryonic stem cell (hESC) self‐renewal. It is shown that dorsomorphin promotes hESC self‐renewal by antagonizing autocrine BMP signaling.