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A Spatially Propagating Biochemical Reaction
Author(s) -
Liao Xiaoli,
Petty Rafe T.,
Mrksich Milan
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005638
Subject(s) - autocatalysis , phosphopeptide , chemistry , sh2 domain , proto oncogene tyrosine protein kinase src , substrate (aquarium) , peptide , kinase , combinatorial chemistry , monolayer , enzyme catalysis , sh3 domain , biophysics , enzyme , biochemistry , catalysis , biology , ecology
Surfing with the kinase : A soluble kinase phosphorylates an immobilized peptide substrate most rapidly at the boundary between product and substrate, and gives rise to a “wave” of propagating product. Such systems offer an approach to engineering reactions to give spatio‐temporal control over progression of reactions.