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Relevant Anion–π Interactions in Biological Systems: The Case of Urate Oxidase
Author(s) -
Estarellas Carolina,
Frontera Antonio,
Quiñonero David,
Deyà Pere M.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005635
Subject(s) - enzyme , chemistry , ion , enzyme inhibition , cyanide , biochemistry , substrate specificity , substrate (aquarium) , combinatorial chemistry , relevance (law) , oxidase test , biology , organic chemistry , ecology , political science , law
Enzyme inhibited : The important role of anion–π interactions that are present in the active site of the urate oxidase enzyme is reported (see picture). The inhibition of this enzyme by cyanide ions is caused by the existence of an anion–π interaction between the inhibitor and the enzymatic substrate. This investigation extends the relevance of anion–π interactions to important fields such as enzyme chemistry.