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Attomolar Detection of a Cancer Biomarker Protein in Serum by Surface Plasmon Resonance Using Superparamagnetic Particle Labels
Author(s) -
Krishnan Sadagopan,
Mani Vigneshwaran,
Wasalathanthri Dhanuka,
Kumar Challa V.,
Rusling James F.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005607
Subject(s) - surface plasmon resonance , superparamagnetism , particle (ecology) , biomarker , nanotechnology , plasmon , resonance (particle physics) , materials science , refractive index , chemistry , optoelectronics , nanoparticle , physics , magnetization , biology , biochemistry , quantum mechanics , magnetic field , ecology , particle physics
Signal amplifiers : Superparamagnetic particle–antibody conjugates were used to detect a cancer biomarker in serum by surface plasmon resonance (SPR) at an unprecedented low level of 10 fg mL −1 (ca. 300 a M ). Ultrahigh sensitivity is facilitated by enhanced mass and refractive index from aggregates of 1 μm magnetic particles on the SPR chip.