Attomolar Detection of a Cancer Biomarker Protein in Serum by Surface Plasmon Resonance Using Superparamagnetic Particle Labels | Zendy

Krishnan Sadagopan | Zendy; Mani Vigneshwaran | Zendy; Wasalathanthri Dhanuka | Zendy; Kumar Challa V. | Zendy; Rusling James F. | Zendy

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Attomolar Detection of a Cancer Biomarker Protein in Serum by Surface Plasmon Resonance Using Superparamagnetic Particle Labels

Author(s) -

Krishnan Sadagopan,

Mani Vigneshwaran,

Wasalathanthri Dhanuka,

Kumar Challa V.,

Rusling James F.

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201005607

Subject(s) - surface plasmon resonance , superparamagnetism , particle (ecology) , biomarker , nanotechnology , plasmon , resonance (particle physics) , materials science , refractive index , chemistry , optoelectronics , nanoparticle , physics , magnetization , biology , biochemistry , quantum mechanics , magnetic field , ecology , particle physics

Signal amplifiers : Superparamagnetic particle–antibody conjugates were used to detect a cancer biomarker in serum by surface plasmon resonance (SPR) at an unprecedented low level of 10 fg mL −1 (ca. 300 a M ). Ultrahigh sensitivity is facilitated by enhanced mass and refractive index from aggregates of 1 μm magnetic particles on the SPR chip.

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