Gephyronic Acid, a Missing Link between Polyketide Inhibitors of Eukaryotic Protein Synthesis (Part I): Structural Revision and Stereochemical Assignment of Gephyronic Acid | Zendy

Nicolas Lionel | Zendy; Anderl Timo | Zendy; Sasse Florenz | Zendy; Steinmetz Heinrich | Zendy; Jansen Rolf | Zendy; Höfle Gerhard | Zendy; Laschat Sabine | Zendy; Taylor Richard E. | Zendy

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Gephyronic Acid, a Missing Link between Polyketide Inhibitors of Eukaryotic Protein Synthesis (Part I): Structural Revision and Stereochemical Assignment of Gephyronic Acid

Author(s) -

Nicolas Lionel,

Anderl Timo,

Sasse Florenz,

Steinmetz Heinrich,

Jansen Rolf,

Höfle Gerhard,

Laschat Sabine,

Taylor Richard E.

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201005530

Subject(s) - polyketide , natural product , stereochemistry , chemistry , total synthesis , combinatorial chemistry , computational biology , biology , biochemistry , biosynthesis , enzyme

Solving the puzzle : The correct structure and configuration of the natural product gephyronic acid has been determined by NMR analysis and correlation with synthetic reference compounds, as well as with myriaporone 4 and tedanolide. Gephyronic acid, isolated from culture supernatants of Archangium gephyra , displays intriguing antibiotic activity.

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