Premium
Gephyronic Acid, a Missing Link between Polyketide Inhibitors of Eukaryotic Protein Synthesis (Part I): Structural Revision and Stereochemical Assignment of Gephyronic Acid
Author(s) -
Nicolas Lionel,
Anderl Timo,
Sasse Florenz,
Steinmetz Heinrich,
Jansen Rolf,
Höfle Gerhard,
Laschat Sabine,
Taylor Richard E.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005530
Subject(s) - polyketide , natural product , stereochemistry , chemistry , total synthesis , combinatorial chemistry , computational biology , biology , biochemistry , biosynthesis , enzyme
Solving the puzzle : The correct structure and configuration of the natural product gephyronic acid has been determined by NMR analysis and correlation with synthetic reference compounds, as well as with myriaporone 4 and tedanolide. Gephyronic acid, isolated from culture supernatants of Archangium gephyra , displays intriguing antibiotic activity.