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Polyvalent Nucleic Acid/Mesoporous Silica Nanoparticle Conjugates: Dual Stimuli‐Responsive Vehicles for Intracellular Drug Delivery
Author(s) -
Chen Cuie,
Geng Jie,
Pu Fang,
Yang Xinjian,
Ren Jinsong,
Qu Xiaogang
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005471
Subject(s) - mesoporous silica , nucleic acid , conjugate , intracellular , drug delivery , nanoparticle , chemistry , dual (grammatical number) , drug , nanotechnology , combinatorial chemistry , mesoporous material , biophysics , biochemistry , pharmacology , materials science , biology , catalysis , art , literature , mathematical analysis , mathematics
Blocked tubes : Attachment of self‐complementary duplex DNA to the openings of mesoporous silica nanoparticles results in a cap for trapping guest molecules. The cargo can be released either by thermal stimuli or by the introduction of DNase I, both of which open the capping DNA structure (see picture).