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Direct Cross‐Coupling of CH Bonds with Grignard Reagents through Cobalt Catalysis
Author(s) -
Li Bin,
Wu ZhenHua,
Gu YiFan,
Sun ChangLiang,
Wang BaiQuan,
Shi ZhangJie
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005394
Subject(s) - aryl , reagent , regioselectivity , reactivity (psychology) , catalysis , cobalt , quinoline , chemistry , combinatorial chemistry , alkyl , grignard reagent , grignard reaction , organic chemistry , medicinal chemistry , medicine , alternative medicine , pathology
Go go Grignard! The first highly regioselective, cobalt‐catalyzed CH transformation of benzo[ h ]quinoline and phenylpyridine derivatives with Grignard reagents at room temperature has been achieved (see scheme). Both aryl and alkyl Grignard reagents showed significant reactivity.