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Identification of a Valuable Kinetic Process in Copper‐Catalyzed Asymmetric Allylic Alkylation
Author(s) -
Langlois JeanBaptiste,
Alexakis Alexandre
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005373
Subject(s) - copper , generality , combinatorial chemistry , kinetic energy , process (computing) , tsuji–trost reaction , identification (biology) , allylic rearrangement , catalysis , chemistry , transformation (genetics) , kinetic resolution , alkylation , computational chemistry , organic chemistry , computer science , enantioselective synthesis , biology , physics , biochemistry , psychology , botany , quantum mechanics , gene , psychotherapist , operating system
Copper bottomed : The application of a previously described process of dynamic kinetic asymmetric transformation to acyclic substrates allowed the identification of a relevant kinetic process in the title reaction (see scheme; CuTC= copper(I) thiophencarboxylate, Naphth= naphthyl). The optimization of the reaction conditions and generality of the method, as well as mechanistic considerations are disclosed.