Asymmetric Iron‐Catalyzed Hydrosilane Reduction of Ketones: Effect of Zinc Metal upon the Absolute Configuration | Zendy

Inagaki Tomohiko | Zendy; Ito Akihiro | Zendy; Ito Junichi | Zendy; Nishiyama Hisao | Zendy

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Asymmetric Iron‐Catalyzed Hydrosilane Reduction of Ketones: Effect of Zinc Metal upon the Absolute Configuration

Author(s) -

Inagaki Tomohiko,

Ito Akihiro,

Ito Junichi,

Nishiyama Hisao

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201005363

Subject(s) - enantiomer , catalysis , zinc , chemistry , absolute configuration , enantiomeric excess , alcohol , metal , reduction (mathematics) , combinatorial chemistry , computer science , enantioselective synthesis , stereochemistry , organic chemistry , mathematics , geometry

Just a little bit : The 1 /FeCl 2 complex was activated in the presence of Zn and exhibited catalytic activity for the hydrosilane reduction of ketones to give the S‐ configured alcohol. In contrast, the mixed‐catalyst system of 1 and Fe(OAc) 2 provides the R enantiomer. This approach provides both enantiomers from a single chiral source by the addition of a small amount of Zn.

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