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Concise Total Synthesis of Sintokamides A, B, and E by a Unified, Protecting‐Group‐Free Strategy
Author(s) -
Gu Zhenhua,
Zakarian Armen
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005354
Subject(s) - group (periodic table) , protecting group , prostate cancer , ruthenium , chemistry , group a , combinatorial chemistry , stereochemistry , catalysis , biochemistry , medicine , cancer , organic chemistry , alkyl
One for all : A group of polychlorinated marine peptides known as sintokamides show intriguing activity against hormone‐refractory prostate cancer cells. Three members of the group have now been synthesized by a general strategy enabled by a ruthenium‐catalyzed radical chloroalkylation of titanium enolates (see scheme).