Premium
Concise Total Synthesis of Sintokamides A, B, and E by a Unified, Protecting‐Group‐Free Strategy
Author(s) -
Gu Zhenhua,
Zakarian Armen
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005354
Subject(s) - group (periodic table) , protecting group , prostate cancer , ruthenium , chemistry , group a , combinatorial chemistry , stereochemistry , catalysis , biochemistry , medicine , cancer , organic chemistry , alkyl
One for all : A group of polychlorinated marine peptides known as sintokamides show intriguing activity against hormone‐refractory prostate cancer cells. Three members of the group have now been synthesized by a general strategy enabled by a ruthenium‐catalyzed radical chloroalkylation of titanium enolates (see scheme).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom