Finding Reaction Pathways for Multicomponent Reactions: The Passerini Reaction is a Four‐Component Reaction | Zendy

Maeda Satoshi | Zendy; Komagawa Shinsuke | Zendy; Uchiyama Masanobu | Zendy; Morokuma Keiji | Zendy

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Finding Reaction Pathways for Multicomponent Reactions: The Passerini Reaction is a Four‐Component Reaction

Author(s) -

Maeda Satoshi,

Komagawa Shinsuke,

Uchiyama Masanobu,

Morokuma Keiji

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201005336

Subject(s) - isocyanide , aldehyde , component (thermodynamics) , ketone , chemistry , reaction mechanism , carboxylic acid , organic chemistry , ugi reaction , molecule , combinatorial chemistry , catalysis , physics , thermodynamics

Route finder : The Passerini three‐component reaction of a carboxylic acid, an aldehyde (or ketone), and an isocyanide to give an α‐acyloxycarboxamide actually follows a four‐component mechanism involving an additional molecule of carboxylic acid (see scheme). The discovery was made by applying a new “reaction route explorer” to the simplest Passerini reaction (HCOOH+HCHO+CH 3 NC).

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