Premium
A Parallel Screen for the Discovery of Novel DNA Base Pairs
Author(s) -
Yaren Oezlem,
Mosimann Markus,
Leumann Christian J.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005300
Subject(s) - base (topology) , duplex (building) , computer science , base pair , information retrieval , dna , computational biology , knowledge base , process (computing) , combinatorial chemistry , world wide web , biology , chemistry , genetics , mathematics , programming language , mathematical analysis
Speed dating : A combinatorial assay was developed for screening a library of aromatic heterocyclic amines for their propensity to act as a complementary base Z in a DNA duplex. This assay may prove useful in speeding up the process of base‐pair discovery for potential applications in biotechnology and synthetic biology.