Tandem Acyl Carrier Proteins in the Curacin Biosynthetic Pathway Promote Consecutive Multienzyme Reactions with a Synergistic Effect | Zendy

Gu Liangcai | Zendy; Eisman Eli B. | Zendy; Dutta Somnath | Zendy; Franzmann Titus M. | Zendy; Walter Stefan | Zendy; Gerwick William H. | Zendy; Skiniotis Georgios | Zendy; Sherman David H. | Zendy

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Tandem Acyl Carrier Proteins in the Curacin Biosynthetic Pathway Promote Consecutive Multienzyme Reactions with a Synergistic Effect

Author(s) -

Gu Liangcai,

Eisman Eli B.,

Dutta Somnath,

Franzmann Titus M.,

Walter Stefan,

Gerwick William H.,

Skiniotis Georgios,

Sherman David H.

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201005280

Subject(s) - biosynthesis , chromosomal translocation , tandem , computational biology , chemistry , biology , biochemistry , gene , materials science , composite material

Synergistic gathering : Biochemical studies reveal a highly efficient strategy in biosynthesis to promote consecutive multienzyme reactions. In the curacin A pathway, catalytic efficiency of a multi‐step modification process and one‐step translocation is significantly enhanced by tandem organization and dimerization of the ACP 3 tridomain with an unexpected synergistic effect (see scheme).

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