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Tandem Acyl Carrier Proteins in the Curacin Biosynthetic Pathway Promote Consecutive Multienzyme Reactions with a Synergistic Effect
Author(s) -
Gu Liangcai,
Eisman Eli B.,
Dutta Somnath,
Franzmann Titus M.,
Walter Stefan,
Gerwick William H.,
Skiniotis Georgios,
Sherman David H.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005280
Subject(s) - biosynthesis , chromosomal translocation , tandem , computational biology , chemistry , biology , biochemistry , gene , materials science , composite material
Synergistic gathering : Biochemical studies reveal a highly efficient strategy in biosynthesis to promote consecutive multienzyme reactions. In the curacin A pathway, catalytic efficiency of a multi‐step modification process and one‐step translocation is significantly enhanced by tandem organization and dimerization of the ACP 3 tridomain with an unexpected synergistic effect (see scheme).