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Peptide Bond Formation on the Ribosome: The Role of the 2′‐OH Group on the Terminal Adenosine of Peptidyl‐tRNA and of the Length of Nascent Peptide Chain
Author(s) -
Huang Yiwei,
Sprinzl Mathias
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005245
Subject(s) - ribosome , transfer rna , peptide bond , peptide , p site , translation (biology) , stereochemistry , ribosomal rna , 50s , adenosine , chemistry , biochemistry , rna , gene , messenger rna
The conformation of the 3′‐terminal ribose is essential for peptide bond formation on the ribosome. The growing peptide chain (see picture) anchored in the ribosomal peptide exit tunnel stabilizes to required conformation and provides the frame for precisely positioning the peptidyl‐tRNA and aminoacyl‐tRNA. The 2′‐OH group on the 3′‐terminal adenosine of peptidyl‐tRNA is not essential.