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Quaternary Carbon Stereogenic Centers through Copper‐Catalyzed Enantioselective Allylic Substitutions with Readily Accessible Aryl‐ or Heteroaryllithium Reagents and Aluminum Chlorides
Author(s) -
Gao Fang,
Lee Yunmi,
Mandai Kyoko,
Hoveyda Amir H.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005124
Subject(s) - stereocenter , enantioselective synthesis , allylic rearrangement , aryl , reagent , catalysis , combinatorial chemistry , carbon fibers , quaternary carbon , chemistry , organic chemistry , stereochemistry , computer science , algorithm , alkyl , composite number
The case of the notorious aryls is solved : The first efficient catalytic and enantioselective method for allylic substitutions that furnish quaternary carbon stereogenic centers by additions of aryl‐ or heteroarylmetals is reported (see scheme). Highly site‐ and enantioselective processes begin with readily available organolithium reagents.