Premium
pH‐Responsive Release of Acetal‐Linked Melittin from SBA‐15 Mesoporous Silica
Author(s) -
Schlossbauer Axel,
Dohmen Christian,
Schaffert David,
Wagner Ernst,
Bein Thomas
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005120
Subject(s) - melittin , peptide , mesoporous silica , acetal , lysis , chemistry , biophysics , mesoporous material , combinatorial chemistry , biochemistry , organic chemistry , biology , catalysis
Free to go : A pH‐labile immobilization of the melittin peptide with acetal linkers in the pore system of a SBA‐15 host allows release of the peptide upon decrease of the pH value from 7.4 to 5.5. Such a release is shown by melittin‐induced lysis of mouse erythrocytes. The method could be used to prepare new silica‐based peptide delivery systems for targeted cancer therapy.