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Pure Protein Microspheres by Calcium Carbonate Templating
Author(s) -
Volodkin Dmitry V.,
von Klitzing Regine,
Möhwald Helmuth
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005089
Subject(s) - dispersity , calcium carbonate , microsphere , chemistry , chemical engineering , mineralogy , computer science , organic chemistry , engineering
Swapping spheres : Monodisperse protein microspheres can be fabricated by templating on porous CaCO 3 microcores (see picture; CaCO 3 gray, insulin orange). The CaCO 3 cores decompose upon variation of pH from 9.0 to 5.0, whereas the insulin model protein precipitates. The method requires mild conditions, no additives, and minimal processing.