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A General Catalyst for the β‐Selective C–H Bond Arylation of Thiophenes with Iodoarenes
Author(s) -
Ueda Kirika,
Yanagisawa Shuichi,
Yamaguchi Junichiro,
Itami Kenichiro
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005082
Subject(s) - thiophene , catalysis , chemistry , selectivity , surface modification , medicinal chemistry , organic chemistry , combinatorial chemistry
Open access : The normally less‐reactive β position of thiophenes was previously inaccessible to direct functionalization. However, the β selectivity observed with the catalytic system PdCl 2 /P{OCH(CF 3 ) 2 } 3 /Ag 2 CO 3 in the arylation of thiophenes with iodoarenes (see scheme) is a remarkably general phenomenon applicable to unsubstituted, monosubstituted, and disubstituted thiophene derivatives, as well as thiophene‐containing fused aromatic compounds.