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Convertible Organic Nanoparticles for Near‐Infrared Photothermal Ablation of Cancer Cells
Author(s) -
Yang Jaemoon,
Choi Jihye,
Bang Doyeon,
Kim Eunjung,
Lim EunKyung,
Park Huiyul,
Suh JinSuck,
Lee Kwangyeol,
Yoo KyungHwa,
Kim EunKyung,
Huh YongMin,
Haam Seungjoo
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005075
Subject(s) - photothermal therapy , nanoparticle , ablation , nanotechnology , tumor ablation , irradiation , absorption (acoustics) , near infrared spectroscopy , polyaniline , materials science , chemistry , optoelectronics , polymer , optics , medicine , physics , organic chemistry , polymerization , nuclear physics , composite material
Infiltrate and destroy : In an environment rich in protonating or oxidative species, such as the intracellular milieu of cancer cells, the main absorption band of spherical, water‐soluble polyaniline nanoparticles was red‐shifted to a near‐infrared (NIR) wavelength as a result of the formation of the emeraldine salt (see picture). The doped nanoparticles caused photothermal ablation of cancer cells upon NIR laser irradiation in vitro and in vivo.