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Mesoporous Silica Nanoparticles End‐Capped with Collagen: Redox‐Responsive Nanoreservoirs for Targeted Drug Delivery
Author(s) -
Luo Zhong,
Cai Kaiyong,
Hu Yan,
Zhao Li,
Liu Peng,
Duan Lin,
Yang Weihu
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005061
Subject(s) - linker , mesoporous silica , moiety , drug delivery , chemistry , nanoparticle , isothiocyanate , nanotechnology , fluorescein isothiocyanate , intracellular , combinatorial chemistry , targeted drug delivery , disulfide bond , redox , biophysics , biochemistry , mesoporous material , computer science , stereochemistry , materials science , organic chemistry , fluorescence , biology , catalysis , physics , quantum mechanics , operating system
If the cap fits : Attachment of collagen (Col) to silica nanoparticles (MSN) by a disulfide linker, followed by introduction of lactobionic acid (LA, a cell‐specific targeting moiety), results in a redox‐responsive system for cell‐specific intracellular drug delivery and efficient endocytosis (see picture). Controlled release of a model drug (fluorescein isothiocyanate, FITC) was achieved by cleavage of the disufide bonds.