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Facile DNA Immobilization on Surfaces through a Catecholamine Polymer
Author(s) -
Ham Hyun Ok,
Liu Zhongqiang,
Lau K. H. Aaron,
Lee Haeshin,
Messersmith Phillip B.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201005001
Subject(s) - polymer , nanotechnology , fabrication , substrate (aquarium) , materials science , dna , chemistry , computer science , biology , biochemistry , composite material , medicine , ecology , alternative medicine , pathology
Simple immersion of noble metals, oxides, semiconductors, and synthetic polymer substrates in a mussel‐mimetic catecholamine polymer solution p(DOMA‐AEMA) leads to formation of a thin film on the substrate. The resulting coated substrates can bind DNA without further surface treatment. This approach provides a new entrance to DNA microarray fabrication.