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Total Synthesis of Tryprostatins A and B
Author(s) -
Yamakawa Takayuki,
Ideue Eiji,
Shimokawa Jun,
Fukuyama Tohru
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004963
Subject(s) - radical cyclization , chemistry , radical initiator , total synthesis , stereochemistry , organic chemistry , polymer , polymerization
A reasonable approach to the radical : The establishment of reliable conditions for the radical‐mediated construction of indoles enabled the highly efficient synthesis of tryprostatins A and B. Use of the radical initiator 2,2′‐azobis(4‐methoxy‐2,4‐dimethylvaleronitrile) has allowed to carry out the radical cyclization at just 30 °C, thereby suppressing the formation of by‐products.