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Rhodium(II)‐Catalyzed Cross‐Coupling of Diazo Compounds
Author(s) -
Hansen Jørn H.,
Parr Brendan T.,
Pelphrey Philip,
Jin Quihui,
Autschbach Jochen,
Davies Huw M. L.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004923
Subject(s) - diazo , rhodium , aryl , combinatorial chemistry , coupling (piping) , nothing , chemistry , computer science , alkyl , catalysis , database , organic chemistry , philosophy , materials science , epistemology , metallurgy
Nothing left to chance : A convenient protocol for selective cross‐coupling of diazo compounds for the convergent synthesis of alkenes was developed (see scheme; EDG=aryl, heteroaryl, vinyl; R=O‐alkyl, aryl). The selectivity control elements were identified by ReactIR and DFT calculations and provide a framework for the design of viable diazo coupling reactions.