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A Simple and General Platform for Generating Stereochemically Complex Polyene Frameworks by Iterative Cross‐Coupling
Author(s) -
Lee Suk Joong,
Anderson Thomas M.,
Burke Martin D.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004911
Subject(s) - polyene , bifunctional , chemistry , combinatorial chemistry , stereochemistry , small molecule , organic chemistry , biochemistry , catalysis
Not so complex : A novel iterative cross‐coupling strategy provides access to useful building blocks that enable the simple preparation of complex polyene natural‐product motifs in all possible stereoisomeric forms. The method was used to synthesize the polyene core of vacidin A (see structure).