Premium
Atom‐Economical Synthesis of Unsymmetrical Ketones through Photocatalyzed CH Activation of Alkanes and Coupling with CO and Electrophilic Alkenes
Author(s) -
Ryu Ilhyong,
Tani Akihiro,
Fukuyama Takahide,
Ravelli Davide,
Fagi Maurizio,
Albini Angelo
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004854
Subject(s) - electrophile , carbonylation , chemistry , alkene , alkane , catalysis , coupling (piping) , radical , atom (system on chip) , medicinal chemistry , combinatorial chemistry , organic chemistry , computer science , materials science , operating system , carbon monoxide , metallurgy
A three‐component coupling between alkanes, CO, and electron‐deficient alkenes in the presence of a catalytic amount of ( n Bu 4 N) 4 W 10 O 32 (TBADT) has resulted in the efficient formation of unsymmetrical ketones. This process is based on the carbonylation of alkyl radicals photocatalytically generated by CH activation of alkanes and the subsequent addition to alkenes (see scheme; EWG=electron‐withdrawing group).